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KMID : 1140220140190020075
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대한암예방학회지
2014 Volume.19 No. 2 p.75 ~ p.88
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Endoplasmic Reticulum Stress and Cancer
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Yadav Raj Kumar
Chae Soo-Wan
Kim Hyung-Ryong
Chae Han-Jung
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Abstract
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The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR. The UPR seems to adjust the paradoxical microenvironment of cancer and, as such, is one of resistance mechanisms against cancer therapy. This review describes the activity of different UPRs involved in tumorigenesis and resistance to cancer therapy.
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KEYWORD
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Endoplasmic reticulum stress, Cancer, Unfolded protein response
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